Acquired and Transmitted Multidrug Resistant Tuberculosis: The Role of Social Determinants | Zendy

Anna Odone | Zendy; Roger Calderón | Zendy; Mercedes C. Becerra | Zendy; Zibiao Zhang | Zendy; Carmen Contreras | Zendy; Rosa Yataco | Zendy; Jerome T. Galea | Zendy; Leonid Lecca | Zendy; Matthew H. Bonds | Zendy; Carole D. Mitnick | Zendy; Megan Murray | Zendy

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Acquired and Transmitted Multidrug Resistant Tuberculosis: The Role of Social Determinants

Author(s) -

Anna Odone,

Roger Calderón,

Mercedes C. Becerra,

Zibiao Zhang,

Carmen Contreras,

Rosa Yataco,

Jerome T. Galea,

Leonid Lecca,

Matthew H. Bonds,

Carole D. Mitnick,

Megan Murray

Publication year - 2016

Publication title -

plos one

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.99

H-Index - 332

ISSN - 1932-6203

DOI - 10.1371/journal.pone.0146642

Subject(s) - tuberculosis , socioeconomic status , medicine , environmental health , drug resistance , prospective cohort study , cohort study , cohort , multiple drug resistance , demography , biology , population , pathology , microbiology and biotechnology , sociology

Although risk factors for multi-drug resistant tuberculosis are known, few studies have differentiated between acquired and transmitted resistance. It is important to identify factors associated with these different mechanisms to optimize control measures. We conducted a prospective cohort study of index TB patients and their household contacts in Lima, Peru to identify risk factors associated with acquired and transmitted resistance, respectively. Patients with higher socioeconomic status (SES) had a 3-fold increased risk of transmitted resistance compared to those with lower SES when acquired resistance served as the baseline. Quality of housing mediated most of the impact of SES.

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