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Helicobacter pylori  ( H .  pylori )  - induced gastric inflammation impacts the functions of leptin- and ghrelin-producing cells in the gastroduodenum. Inflammation resulting from  H .  pylori  sensing via Toll-like receptors (TLRs) and the associated downstream signaling largely remain ambiguous. Here, we investigated the role of gut hormones, pro-inflammatory cytokines and single nucleotide polymorphisms (SNPs) associated with TLR 4p14 in  H .  pylori  disease in 30 subjects with non-ulcer dyspepsia (NUD), 40 with peptic ulcer disease (PUD) and 15 with gastric cancer (GC) subjects positive and negative for  H .  pylori  infection. The level of pro-inflammatory cytokines was directly proportional to the severity of gastritis, and disease status influenced the levels of gut hormones and pro-inflammatory cytokines.  TLR-1  SNPs  rs4833095 and TLR-10  SNPs  rs10004195  and were directly associated with  H .  pylori  disease, and were up-regulated in the presence of  H .  pylori  in a genotype-independent manner. We concluded that  TLR-1 rs4833095  and  TLR10 rs10004195  confer susceptibility to development of gastroduodenal disease, especially GC in  H . pylori  disease.

Polymorphisms at Locus 4p14 of Toll-Like Receptors TLR-1 and TLR-10 Confer Susceptibility to Gastric Carcinoma in Helicobacter pylori Infection