A Strontium-Modified Titanium Surface Produced by a New Method and Its Biocompatibility In Vitro | Zendy

Chundong Liu | Zendy; Yanli Zhang | Zendy; Lichao Wang | Zendy; Xinhua Zhang | Zendy; Qiuyue Chen | Zendy; Buling Wu | Zendy

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A Strontium-Modified Titanium Surface Produced by a New Method and Its Biocompatibility In Vitro

Author(s) -

Chundong Liu,

Yanli Zhang,

Lichao Wang,

Xinhua Zhang,

Qiuyue Chen,

Buling Wu

Publication year - 2015

Publication title -

plos one

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.99

H-Index - 332

ISSN - 1932-6203

DOI - 10.1371/journal.pone.0140669

Subject(s) - strontium , biocompatibility , titanium , calvaria , surface modification , chemistry , adhesion , osteoblast , in vitro , materials science , nuclear chemistry , biochemistry , metallurgy , organic chemistry

Objective To present a new and effective method of producing titanium surfaces modified with strontium and to investigate the surface characteristics and in vitro biocompatibility of titanium (Ti) surfaces modified with strontium (Sr) for bone implant applications. Materials and Methods Sr-modified Ti surfaces were produced by sequential treatments with NaOH, strontium acetate, heat and water. The surface characteristics and the concentration of the Sr ions released from the samples were examined. Cell adhesion, morphology and growth were investigated using osteoblasts isolated from the calvaria of neonatal Sprague-Dawley rats. Expression of osteogenesis-related genes and proteins was examined to assess the effect of the Sr-modified Ti surfaces on osteoblasts. Results The modified titanium surface had a mesh structure with significantly greater porosity, and approximately5.37±0.35at.% of Sr was incorporated into the surface. The hydrophilicity was enhanced by the incorporation of Sr ions and water treatment. The average amounts of Sr released from the Sr-modified plates subjected to water treatment were slight higher than the plates without water treatment. Sr promoted cellular adhesion, spreading and growth compared with untreated Ti surfaces. The Sr-modified Ti plates also promoted expression of osteogenesis-related genes,and expression of OPN and COL-І by osteoblasts. Ti plates heat treated at 700°C showed increased bioactivity in comparison with those treated at 600°C. Water treatment upregulated the expression of osteogenesis-related genes. Conclusions These results show that Sr-modification of Ti surfaces may improve bioactivity in vitro . Water treatment has enhanced the response of osteoblasts. The Sr-modified Ti heat-treated at 700°C exhibited better bioactivity compared with that heated at 600°C.

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