Polyanionic Carboxyethyl Peptide Nucleic Acids (ce-PNAs): Synthesis and DNA Binding | Zendy

Yu. G. Kirillova | Zendy; N. P. Boyarskaya | Zendy; A. V. Dezhenkov | Zendy; Mariya Tankevich | Zendy; Ivan Prokhorov | Zendy; Anna M. Varizhuk | Zendy; Sergei Eremin | Zendy; Д. С. Есипов | Zendy; Igor P. Smirnov | Zendy; Galina E. Pozmogova | Zendy

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Polyanionic Carboxyethyl Peptide Nucleic Acids (ce-PNAs): Synthesis and DNA Binding

Author(s) -

Yu. G. Kirillova,

N. P. Boyarskaya,

A. V. Dezhenkov,

Mariya Tankevich,

Ivan Prokhorov,

Anna M. Varizhuk,

Sergei Eremin,

Д. С. Есипов,

Igor P. Smirnov,

Galina E. Pozmogova

Publication year - 2015

Publication title -

plos one

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.99

H-Index - 332

ISSN - 1932-6203

DOI - 10.1371/journal.pone.0140468

Subject(s) - peptide nucleic acid , nucleic acid , dna , monomer , thymine , chemistry , peptide , nucleic acid thermodynamics , mass spectrometry , circular dichroism , biochemistry , combinatorial chemistry , rna , stereochemistry , organic chemistry , polymer , chromatography , gene , base sequence

New polyanionic modifications of polyamide nucleic acid mimics were obtained. Thymine decamers were synthesized from respective chiral α- and γ-monomers, and their enantiomeric purity was assessed. Here, we present the decamer synthesis, purification and characterization by MALDI-TOF mass spectrometry and an investigation of the hybridization properties of the decamers. We show that the modified γ- S -carboxyethyl-T 10 PNA forms a stable triplex with polyadenine DNA.

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