Euphol from Euphorbia tirucalli Negatively Modulates TGF-β Responsiveness via TGF-β Receptor Segregation inside Membrane Rafts | Zendy

ChunLin Chen | Zendy; YingPin Chen | Zendy; MingWei Lin | Zendy; YawBin Huang | Zendy; FangRong Chang | Zendy; TsaiHui Duh | Zendy; DengChyang Wu | Zendy; WeiChiang Wu | Zendy; Yu-Chen Kao | Zendy; Pei-Hua Yang | Zendy

Open Access

Euphol from Euphorbia tirucalli Negatively Modulates TGF-β Responsiveness via TGF-β Receptor Segregation inside Membrane Rafts

Author(s) -

ChunLin Chen,

YingPin Chen,

MingWei Lin,

YawBin Huang,

FangRong Chang,

TsaiHui Duh,

DengChyang Wu,

WeiChiang Wu,

Yu-Chen Kao,

Pei-Hua Yang

Publication year - 2015

Publication title -

plos one

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.99

H-Index - 332

ISSN - 1932-6203

DOI - 10.1371/journal.pone.0140249

Subject(s) - caveolae , lipid raft , endocytosis , microbiology and biotechnology , transforming growth factor , lipid microdomain , signal transduction , receptor , internalization , receptor mediated endocytosis , clathrin , biology , chemistry , biochemistry , membrane

Transforming growth factor-β (TGF-β) responsiveness in cultured cells can be modulated by TGF-β partitioning between lipid raft/caveolae- and clathrin-mediated endocytosis pathways. Lipid rafts are plasma membrane microdomains with an important role in cell survival signaling, and cholesterol is necessary for the lipid rafts’ structure and function. Euphol is a euphane-type triterpene alcohol that is structurally similar to cholesterol and has a wide range of pharmacological properties, including anti-inflammatory and anti-cancer effects. In the present study, euphol suppressed TGF-β signaling by inducing TGF-β receptor movement into lipid-raft microdomains and degrading TGF-β receptors.

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