The Functional Study of the N-Terminal Region of Influenza B Virus Nucleoprotein | Zendy

Ming Liu | Zendy; Mandy Ka-Han Lam | Zendy; Qinfen Zhang | Zendy; Ruth A. Elderfield | Zendy; William Barclay | Zendy; PangChui Shaw | Zendy

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The Functional Study of the N-Terminal Region of Influenza B Virus Nucleoprotein

Author(s) -

Ming Liu,

Mandy Ka-Han Lam,

Qinfen Zhang,

Ruth A. Elderfield,

William Barclay,

PangChui Shaw

Publication year - 2015

Publication title -

plos one

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.99

H-Index - 332

ISSN - 1932-6203

DOI - 10.1371/journal.pone.0137802

Subject(s) - nucleoprotein , ribonucleoprotein , virology , virus , influenza a virus , genome , biology , viral replication , viral matrix protein , rna , transcription (linguistics) , chemistry , microbiology and biotechnology , gene , genetics , linguistics , philosophy

Influenza nucleoprotein (NP) is a major component of the ribonucleoprotein (vRNP) in influenza virus, which functions for the transcription and replication of viral genome. Compared to the nucleoprotein of influenza A (ANP), the N-terminal region of influenza B nucleoprotein (BNP) is much extended. By virus reconstitution, we found that the first 38 residues are essential for viral growth. We further illustrated the function of BNP by mini-genome reconstitution, fluorescence microscopy, electron microscopy, light scattering and gel shift. Results show that the N terminus is involved in the formation of both higher homo-oligomers of BNP and BNP-RNA complex.

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