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This study aimed to evaluate protection induced by the vaccine candidate  B .  ovis ΔabcBA  against experimental challenge with wild type  B .  ovis  in rams. Rams were subcutaneously immunized with  B .  ovis  Δ abcBA  encapsulated with sterile alginate or with the non encapsulated vaccine strain. Serum, urine, and semen samples were collected during two months after immunization. The rams were then challenged with wild type  B .  ovis  (ATCC25840), and the results were compared to non immunized and experimentally challenged rams. Immunization, particularly with encapsulated  B .  ovis  Δ abcBA , prevented infection, secretion of wild type  B .  ovis  in the semen and urine, shedding of neutrophils in the semen, and the development of clinical changes, gross and microscopic lesions induced by the wild type  B .  ovis  reference strain. Collectively, our data indicates that the  B .  ovis  Δ abcBA  strain is an exceptionally good vaccine strain for preventing brucellosis caused by  B .  ovis  infection in rams.

Encapsulated Brucella ovis Lacking a Putative ATP-Binding Cassette Transporter (ΔabcBA) Protects against Wild Type Brucella ovis in Rams