miR-378b Promotes Differentiation of Keratinocytes through NKX3.1 | Zendy

Xiliang Wang | Zendy; Tao Zhang | Zendy; Jing Wang | Zendy; Dianbao Zhang | Zendy; Feng Zhao | Zendy; Xuewen Lin | Zendy; Zhe Wang | Zendy; Ping Shi | Zendy; Xining Pang | Zendy

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miR-378b Promotes Differentiation of Keratinocytes through NKX3.1

Author(s) -

Xiliang Wang,

Tao Zhang,

Jing Wang,

Dianbao Zhang,

Feng Zhao,

Xuewen Lin,

Zhe Wang,

Ping Shi,

Xining Pang

Publication year - 2015

Publication title -

plos one

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.99

H-Index - 332

ISSN - 1932-6203

DOI - 10.1371/journal.pone.0136049

Subject(s) - microrna , gene silencing , keratinocyte , cellular differentiation , luciferase , microbiology and biotechnology , rna interference , biology , rna , cell culture , transfection , genetics , gene

MicroRNA (miRNA) is a kind of short non-coding RNA, involved in various cellular processes. During keratinocyte differentiation, miRNAs act as important regulators. In this study, we demonstrated by microarray assay that the expression of miR-378b significantly increased during keratinocytes differentiation. Our findings showed that miR-378b could inhibit proliferation, migration and differentiation in keratinocytes. Luciferase reporter assays showed that miR-378b directly target NKX3.1. Silencing of NKX3.1 could coincide with the effects of miR-24 overexpression. In conclusion, our results demonstrate miR-378b promote keratinocytes differentiation by targeting NKX3.1. Manipulation of miR-378b may afford a new strategy to clinic treatment of skin injury and repair.

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