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We report the genome sequence of  Planobispora rosea  ATCC 53733, a mycelium-forming soil-dweller belonging to one of the lesser studied genera of  Actinobacteria  and producing the thiopeptide GE2270. The  P .  rosea  genome presents considerable convergence in gene organization and function with other members in the family  Streptosporangiaceae , with a significant number (44%) of shared orthologs. Patterns of gene expression in  P .  rosea  cultures during exponential and stationary phase have been analyzed using whole transcriptome shotgun sequencing and by proteome analysis. Among the differentially abundant proteins, those involved in protein metabolism are particularly represented, including the GE2270-insensitive EF-Tu. Two proteins from the  pbt  cluster, directing GE2270 biosynthesis, slightly increase their abundance values over time. While GE2270 production starts during the exponential phase, most  pbt  genes, as analyzed by qRT-PCR, are down-regulated. The exception is represented by  pbtA , encoding the precursor peptide of the ribosomally synthesized GE2270, whose expression reached the highest level at the entry into stationary phase.

A Genomic, Transcriptomic and Proteomic Look at the GE2270 Producer Planobispora rosea, an Uncommon Actinomycete