Gene Transcriptional and Metabolic Profile Changes in Mimetic Aging Mice Induced by D-Galactose | Zendy

Yueyue Zhou | Zendy; Xiong-Fei Ji | Zendy; Jianping Fu | Zendy; Xiaojuan Zhu | Zendy; Ronghua Li | Zendy; Changkao Mu | Zendy; Chunlin Wang | Zendy; Weiwei Song | Zendy

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Gene Transcriptional and Metabolic Profile Changes in Mimetic Aging Mice Induced by D-Galactose

Author(s) -

Yueyue Zhou,

Xiong-Fei Ji,

Jianping Fu,

Xiaojuan Zhu,

Ronghua Li,

Changkao Mu,

Chunlin Wang,

Weiwei Song

Publication year - 2015

Publication title -

plos one

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.99

H-Index - 332

ISSN - 1932-6203

DOI - 10.1371/journal.pone.0132088

Subject(s) - galactose , glycation , gene expression , oxidative stress , oxidative phosphorylation , carbohydrate metabolism , biology , chemistry , biochemistry , gene , endocrinology , diabetes mellitus

D-galactose injection has been shown to induce many changes in mice that represent accelerated aging. This mouse model has been widely used for pharmacological studies of anti-aging agents. The underlying mechanism of D-galactose induced aging remains unclear, however, it appears to relate to glucose and 1ipid metabolic disorders. Currently, there has yet to be a study that focuses on investigating gene expression changes in D-galactose aging mice. In this study, integrated analysis of gas chromatography/mass spectrometry-based metabonomics and gene expression profiles was used to investigate the changes in transcriptional and metabolic profiles in mimetic aging mice injected with D-galactose. Our findings demonstrated that 48 mRNAs were differentially expressed between control and D-galactose mice, and 51 potential biomarkers were identified at the metabolic level. The effects of D-galactose on aging could be attributed to glucose and 1ipid metabolic disorders, oxidative damage, accumulation of advanced glycation end products (AGEs), reduction in abnormal substance elimination, cell apoptosis, and insulin resistance.

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