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Objective  NUCB2/nesfatin-1 is an anorexigenic hormone with elevated levels in obese and decreased levels in anorexia nervosa (AN) patients. Moreover, a role in the regulation of stress and emotions was suggested by several rodent and preliminary human studies. Since anxiety and depression are common comorbidities in AN, we investigated the association of NUCB2/nesfatin-1 with anxiety, depression and perceived stress in AN.    Methods  We analyzed circulating NUCB2/nesfatin-1 levels in 64 female inpatients diagnosed with anorexia nervosa (body mass index, BMI; mean±SD, 14.7±2.3 kg/m 2 ). At the same time anxiety (GAD-7), depression (PHQ-9), stress (PSQ-20) and disordered eating (EDI-2) were measured psychometrically.    Results  No correlation was observed between NUCB2/nesfatin-1 and BMI ( r  = 0.06,  p  = 0.70). The study population was divided in patients with low anxiety (n = 32, GAD-7 scores, mean±SD, 7.5±3.3) and high anxiety (n = 32, 16.0±3.0,  p <0.001). Patients with high anxiety scores displayed 65% higher NUCB2/nesfatin-1 levels ( p  = 0.04). This was reflected by a positive correlation of GAD-7 and NUCB2/nesfatin-1-levels ( r  = 0.32,  p  = 0.04). Scores of PSQ-20 (73.3±14.3  vs . 48.6±17.2) and PHQ-9 (18.8±5.0  vs . 10.3±5.1) were higher in the high anxiety group ( p <0.001) but did not correlate with NUCB2/nesfatin-1 ( p >0.05). EDI-2 total score was also higher in the high anxiety group (52.3±14.1  vs . 40.2±16.0,  p  = 0.02), while no correlations of EDI-2-scores with plasma NUCB2/nesfatin-1 were observed ( p >0.05).    Conclusions  Circulating NUCB2/nesfatin-1 levels correlated positively with perceived anxiety, whereas no association with BMI or eating disorder symptoms was observed. NUCB2/nesfatin-1 might be primarily involved in the modulation of anxiety and subsequently in the regulation of eating habits and body weight in AN.

NUCB2/nesfatin-1 Is Associated with Elevated Levels of Anxiety in Anorexia Nervosa