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Paracoccidioidomycosis (PCM), caused by  Paracoccidioides  species is a prevalent systemic and progressive mycosis that occurs in Latin America. It is caused by  Paracoccidioides  species. Immunization with dendritic cells transfected with a plasmid encoding the scFv (pMAC/PS-scFv) that mimics the main antigen of  P .  brasiliensis  (gp43) confers protection in experimental PCM. DCs link innate and adaptive immunity by recognizing invading pathogens and selecting the type of effector T cell to mediate the immune response. Here, we showed that DC-pMAC/PS-scFv induces the activation of CD4 +  and CD8 +  T cells. Moreover, our results demonstrated that BALB/c mice infected with  P .  brasiliensis  and treated with DC-pMAC/PS-scFv showed the induction of specific IgG production against gp43 and IFN-γ, IL-12 and IL-4 cytokines. Analysis of regional lymph nodes revealed increases in the expression of  clec7a ,  myd88 ,  tlr2 ,  gata3  and  tbx21 , which are involved in the immune response. Taken together, our results indicate that the scFv modulates the humoral and cellular immune responses and presents epitopes to CD4 +  and CD8 +  T cells.

scFv from Antibody That Mimics gp43 Modulates the Cellular and Humoral Immune Responses during Experimental Paracoccidioidomycosis