Both Hepatic and Body Iron Stores Are Increased in Dysmetabolic Iron Overload Syndrome. A Case-Control Study | Zendy

Caroline Jézéquel | Zendy; Fabrice Lainé | Zendy; Bruno Laviolle | Zendy; Anita Kiani | Zendy; Edouard BardouJacquet | Zendy; Yves Deugnier | Zendy

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Both Hepatic and Body Iron Stores Are Increased in Dysmetabolic Iron Overload Syndrome. A Case-Control Study

Author(s) -

Caroline Jézéquel,

Fabrice Lainé,

Bruno Laviolle,

Anita Kiani,

Edouard BardouJacquet,

Yves Deugnier

Publication year - 2015

Publication title -

plos one

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.99

H-Index - 332

ISSN - 1932-6203

DOI - 10.1371/journal.pone.0128530

Subject(s) - ferritin , phlebotomy , medicine , case control study , overweight , serum ferritin , prospective cohort study , iron status , gastroenterology , endocrinology , physiology , iron deficiency , obesity , anemia

Background & Aims Hepatic iron is increased in dysmetabolic iron overload syndrome (DIOS). Whether this reflects elevated body iron stores is still debated. The study was aimed at assessing body iron stores in DIOS patients by calculating the amount of mobilized iron (AMI). Methods We conducted a prospective case-control study comparing AMI in 12 DIOS patients and 12 overweight normoferritinemic subjects matched on BMI and age. All participants were phlebotomized until serum ferritin dropped ≤ 50μg/L. Results The two groups were comparable with respect to metabolic abnormalities and differed according to serum ferritin levels only. AMI was significantly (p<0.0001) higher in DIOS (2.5g±0.7) than in controls (0.8g±0.3). No side effects were related to phlebotomies.

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