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Cancer patients seek alternative remedies such as traditional medicinal plants for safe and effective treatment and help overcome the side effects of conventional therapy. Current knowledge indicates that extracts of  Strobilanthes crispus  of the Acanthaceae family exhibit potent anticancer properties  in vitro  and are non-toxic  in vivo .  S .  crispus  was also reported to be protective against chemical hepatocarcinogenesis. We previously showed that a bioactive fraction of  S .  crispus  leaves also synergized with tamoxifen to cause apoptosis of human breast cancer cell lines without damaging non-malignant epithelial cells. The present study aimed to evaluate the antitumor effect of  S .  crispus  dichloromethane fraction (F3) using N-methyl-N-Nitrosourea (NMU)-induced rat mammary tumor model. Tumor regression was observed in 75% of the rats following 8-week oral administration of F3 with no secondary tumour formation and no signs of anemia or infection. However, no improvement in the liver and renal function profiles was observed. Major constituents of F3 were identified as lutein, 13 1 -hydroxy-13 2 -oxo-pheophytin a, campesterol, stigmasterol, β-sitosterol, pheophytin a and 13 2 -hydroxy-pheophytin a. These compounds however, may not significantly contribute to the antitumor effect of F3.

plos one

Anti-Tumor Action, Clinical Biochemistry Profile and Phytochemical Constituents of a Pharmacologically Active Fraction of S. crispus in NMU-Induced Rat Mammary Tumour Model