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The human Caco-2 cell monolayer model was used to investigate the absorption property, mechanism, and structure-property relationship of seven representative flavonoids, namely, orientin, vitexin, 2”- O -β-L-galactopyranosylorientin, 2”- O -β-L-galactopyranosylvitexin, isoswertisin, isoswertiajaponin, and 2”- O -(2”‘-methylbutanoyl)isoswertisin from the flowers of  Trollius chinensis . The results showed that these flavonoids were hardly transported through the Caco-2 cell monolayer. The compounds with 7-OCH 3  including isoswertisin, isoswertiajaponin and 2”- O -(2”‘-methylbutanoyl)isoswertisin were absorbed in a passive diffusion manner, and their absorbability was increased in the same order as their polarity. The absorption of the remaining compounds with 7-OH including orientin, vitexin, 2”- O -β-L-galactopyranosylorientin, and 2”- O -β-L-galactopyranosylvitexin involved transporter mediated efflux in addition to passive diffusion. Among the four compounds with 7-OH, those with a free hydroxyl group at C-2” such as orientin and vitexin were the substrates of P-glycoprotein (P-gp) and that with a free hydroxyl group at C-2’ such as 2”- O -β-L-galactopyranosylorientin was the substrate of multidrug resistance protein 2 (MRP2). The results of this study also implied that the absorbability of the flavonoids should be taken into account when estimating the effective components of  T .  chinensis .

Characterization of the Intestinal Absorption of Seven Flavonoids from the Flowers of Trollius chinensis Using the Caco-2 Cell Monolayer Model