English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Insecticide-resistant  Drosophila melanogaster  strains represent a resource for the discovery of the underlying molecular mechanisms of cytochrome P450 constitutive over-expression, even if some of these P450s are not directly involved in the resistance phenotype. For example, in select 4,4’-dichlorodiphenyltrichloroethane (DDT) resistant strains the glucocorticoid receptor-like (GR-like) potential transcription factor binding motifs (TFBMs) have previously been shown to be associated with constitutively differentially-expressed cytochrome P450s,  Cyp12d1 ,  Cyp6g2  and  Cyp9c1 . However, insects are not known to have glucocorticoids. The only ortholog to the mammalian glucocorticoid receptor (GR) in  D. melanogaster  is an estrogen-related receptor ( ERR ) gene, which has two predicted alternative splice isoforms ( ERRa  and  ERRb ). Sequencing of  ERRa  and  ERRb  in select DDT susceptible and resistant  D. melanogaster  strains has revealed a glycine (G) codon insertion which was only observed in the ligand binding domain of ERR from the resistant strains tested ( ERR-G ). Transgenic flies, expressing the  ERRa-G  allele, constitutively over-expressed  Cyp12d1 ,  Cyp6g2  and  Cyp9c1 . Only  Cyp12d1  and  Cyp6g2  were over-expressed in the  ERRb-G  transgenic flies. Phylogenetic studies show that the G-insertion appeared to be located in a less conserved domain in ERR and this insertion is found in multiple species across the Sophophora subgenera.

plos one

A Glycine Insertion in the Estrogen-Related Receptor (ERR) Is Associated with Enhanced Expression of Three Cytochrome P450 Genes in Transgenic Drosophila melanogaster