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While  Streptococcus suis  serotype 2 is known to cause severe infections in pigs, it can also be isolated from the tonsils of healthy animals that do not develop infections. We hypothesized that  S. suis  strains in healthy carrier pigs may have the ability to produce bacteriocins, which may contribute to preventing infections by pathogenic  S. suis  strains. Two of ten  S. suis  serotype 2 strains isolated from healthy carrier pigs exhibited antibacterial activity against pathogenic  S. suis  isolates. The bacteriocin produced by  S. suis  3908 was purified to homogeneity using a three-step procedure: ammonium sulfate precipitation, cationic exchange HPLC, and reversed-phase HPLC. The bacteriocin, called suicin 3908, had a low molecular mass; was resistant to heat, pH, and protease treatments; and possessed membrane permeabilization activity. Additive effects were obtained when suicin 3908 was used in combination with penicillin G or amoxicillin. The amino acid sequence of suicin 3908 suggested that it is lantibiotic-related and made it possible to identify a bacteriocin locus in the genome of  S. suis  D12. The putative gene cluster involved in suicin production by  S. suis  3908 was amplified by PCR, and the sequence analysis revealed the presence of nine open reading frames (ORFs), including the structural gene and those required for the modification of amino acids, export, regulation, and immunity. Suicin 3908, which is encoded by the  suiA  gene, exhibited approximately 50% identity with bovicin HJ50 ( Streptococcus bovis ), thermophilin 1277 ( Streptococcus thermophilus ), and macedovicin ( Streptococcus macedonicus ). Given that  S. suis  3908 cannot cause infections in animal models, that it is susceptible to conventional antibiotics, and that it produces a bacteriocin with antibacterial activity against all pathogenic  S. suis  strains tested, it could potentially be used to prevent infections and to reduce antibiotic use by the swine industry.

Suicin 3908, a New Lantibiotic Produced by a Strain of Streptococcus suis Serotype 2 Isolated from a Healthy Carrier Pig