Selective Augmentation of Stem Cell Populations in Structural Fat Grafts for Maxillofacial Surgery | Zendy

Luigi Clauser | Zendy; Letizia Ferroni | Zendy; Chiara Gardin | Zendy; Riccardo Tieghi | Zendy; Manlio Galiè | Zendy; Giovanni Elia | Zendy; Adriano Piattelli | Zendy; Paolo Pinton | Zendy; Eriberto Bressan | Zendy; Barbara Zavan | Zendy

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Selective Augmentation of Stem Cell Populations in Structural Fat Grafts for Maxillofacial Surgery

Author(s) -

Luigi Clauser,

Letizia Ferroni,

Chiara Gardin,

Riccardo Tieghi,

Manlio Galiè,

Giovanni Elia,

Adriano Piattelli,

Paolo Pinton,

Eriberto Bressan,

Barbara Zavan

Publication year - 2014

Publication title -

plos one

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.99

H-Index - 332

ISSN - 1932-6203

DOI - 10.1371/journal.pone.0110796

Subject(s) - liposuction , centrifugation , adipose tissue , stem cell , mesenchymal stem cell , differential centrifugation , biology , microbiology and biotechnology , biomedical engineering , pathology , andrology , surgery , medicine , biochemistry

Structural fat grafting utilizes the centrifugation of liposuction aspirates to create a graded density of adipose tissue. This study was performed to qualitatively investigate the effects of centrifugation on stem cells present in adipose tissue. Liposuction aspirates were obtained from healthy donors and either not centrifuged or centrifuged at 1,800 rpm for 3 minutes. The obtained fat volumes were divided into three layers and then analyzed. The results demonstrate that centrifugation induces a different distribution of stem cells in the three layers. The high-density layer displays the highest expression of mesenchymal stem cell and endothelial markers. The low-density layer exhibits an enrichment of multipotent stem cells. We conclude that appropriate centrifugation concentrates stem cells. This finding may influence the clinical practice of liposuction aspirate centrifugation and enhance graft uptake.

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