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Mutations in the tumor suppressor gene  PTEN  are associated with a significant proportion of human cancers. Because the human genome also contains several homologs of  PTEN , we considered the hypothesis that if a homolog, functionally redundant with PTEN, can be overexpressed, it may rescue the defects of a  PTEN  mutant. We have performed an initial test of this hypothesis in the model system  Dictyostelium discoideum , which contains an ortholog of human  PTEN ,  ptenA . Deletion of  ptenA  results in defects in motility, chemotaxis, aggregation and multicellular morphogenesis.  D. discoideum  also contains  lpten , a newly discovered homolog of  ptenA.  Overexpressing  lpten  completely rescues all developmental and behavioral defects of the  D. discoideum  mutant  ptenA −  . This hypothesis must now be tested in human cells.

plos one

PTEN Redundancy: Overexpressing lpten, a Homolog of Dictyostelium discoideum ptenA, the Ortholog of Human PTEN, Rescues All Behavioral Defects of the Mutant ptenA−