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Ferric uptake regulator (Fur) is a transcriptional regulator that controls the expression of genes involved in the uptake of iron and manganese, as well as vital nutrients, and is essential for intracellular redox cycling. We identified a unique Fur homolog (DR0865) from  Deinococcus radiodurans , which is known for its extreme resistance to radiation and oxidants. A  dr0865  mutant (Mt-0865) showed a higher sensitivity to manganese stress, hydrogen peroxide, gamma irradiation and ultraviolet (UV) irradiation than the wild-type R1 strain. Cellular manganese (Mn) ion (Mn 2+ ) analysis showed that Mn 2+ , copper (Cu 2+ ), and ferric (Fe 3+ ) ions accumulated significantly in the mutant, which suggests that the  dr0865  gene is not only involved in the regulation of Mn 2+  homeostasis, but also affects the uptake of other ions. In addition, transcriptome profiles under MnCl 2  stress showed that the expression of many genes involved in Mn metabolism was significantly different in the wild-type R1 and DR0865 mutant (Mt-0865). Furthermore, we found that the  dr0865  gene serves as a positive regulator of the manganese efflux pump gene  mntE  ( dr1236 ), and as a negative regulator of Mn ABC transporter genes, such as  dr2283 ,  dr2284  and  dr2523 . Therefore, it plays an important role in maintaining the homoeostasis of intracellular Mn (II), and also other Mn 2+ , zinc (Zn 2+ ) and Cu 2+  ions. Based on its role in manganese homeostasis, DR0865 likely belongs to the Mur sub-family of Fur homolog.

A Mur Regulator Protein in the Extremophilic Bacterium Deinococcus radiodurans