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Extensive infiltration of the surrounding healthy brain tissue is a critical feature in glioblastoma. Several miRNAs have been related to gliomagenesis, some of them related with the EGFR pathway. We have evaluated whole-genome miRNA expression profiling associated with different  EGFR  amplification patterns, studied by fluorescence  in situ  hybridization in tissue microarrays, of 30 cases of primary glioblastoma multiforme, whose clinicopathological and immunohistochemical features have also been analyzed. MicroRNA-200c showed a very significant difference between tumors having or not  EGFR  amplification. This microRNA plays an important role in epithelial-mesenchymal transition, but its implication in the behavior of glioblastoma is largely unknown. With respect to  EGFR  status our cases were categorized into three groups: high level  EGFR  amplification, low level  EGFR  amplification, and no  EGFR  amplification. Our results showed that microRNA-200c and E-cadherin expression are down-regulated, while ZEB1 is up-regulated, when tumors showed a high level of  EGFR  amplification. Conversely, ZEB1 mRNA expression levels were significantly lower in the group of tumors without  EGFR  amplification. Tumors with a low level of  EGFR  amplification showed  ZEB1  expression levels comparable to those detected in the group with a high level of amplification. In this study we provide what is to our knowledge the first report of association between microRNA-200c and  EGFR  amplification in glioblastomas.

Correlation between EGFR Amplification and the Expression of MicroRNA-200c in Primary Glioblastoma Multiforme