Progressively Increased M50 Responses to Repeated Sounds in Autism Spectrum Disorder with Auditory Hypersensitivity: A Magnetoencephalographic Study | Zendy

Junko Matsuzaki | Zendy; Kuriko KagitaniShimono | Zendy; Hisato Sugata | Zendy; Masayuki Hirata | Zendy; Ryuzo Hanaie | Zendy; Fumiyo Nagatani | Zendy; Masaya Tachibana | Zendy; Koji Tominaga | Zendy; Ikuko Mohri | Zendy; Masako Taniike | Zendy

Open Access

Progressively Increased M50 Responses to Repeated Sounds in Autism Spectrum Disorder with Auditory Hypersensitivity: A Magnetoencephalographic Study

Author(s) -

Junko Matsuzaki,

Kuriko KagitaniShimono,

Hisato Sugata,

Masayuki Hirata,

Ryuzo Hanaie,

Fumiyo Nagatani,

Masaya Tachibana,

Koji Tominaga,

Ikuko Mohri,

Masako Taniike

Publication year - 2014

Publication title -

plos one

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.99

H-Index - 332

ISSN - 1932-6203

DOI - 10.1371/journal.pone.0102599

Subject(s) - auditory cortex , audiology , sensory gating , autism spectrum disorder , magnetoencephalography , medicine , sensory system , sensory processing , auditory system , psychology , autism , neuroscience , gating , electroencephalography , psychiatry

The aim of this study was to investigate the differential time-course responses of the auditory cortex to repeated auditory stimuli in children with autism spectrum disorder (ASD) showing auditory hypersensitivity. Auditory-evoked field values were obtained from 21 boys with ASD (12 with and 9 without auditory hypersensitivity) and 15 age-matched typically developing controls. M50 dipole moments were significantly increased during the time-course study only in the ASD with auditory hypersensitivity compared with those for the other two groups. The boys having ASD with auditory hypersensitivity also showed more prolonged response duration than those in the other two groups. The response duration was significantly related to the severity of auditory hypersensitivity. We propose that auditory hypersensitivity is associated with decreased inhibitory processing, possibly resulting from an abnormal sensory gating system or dysfunction of inhibitory interneurons.

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