Efficient Induction of Apoptosis by Wee1 Kinase Inhibition in Hepatocellular Carcinoma Cells | Zendy

Tomomi Kogiso | Zendy; Hikaru Nagahara | Zendy; Etsuko Hashimoto | Zendy; Shunichi Ariizumi | Zendy; Masakazu Yamamoto | Zendy; Keiko Shiratori | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Efficient Induction of Apoptosis by Wee1 Kinase Inhibition in Hepatocellular Carcinoma Cells

Author(s) -

Tomomi Kogiso,

Hikaru Nagahara,

Etsuko Hashimoto,

Shunichi Ariizumi,

Masakazu Yamamoto,

Keiko Shiratori

Publication year - 2014

Publication title -

plos one

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.99

H-Index - 332

ISSN - 1932-6203

DOI - 10.1371/journal.pone.0100495

Subject(s) - wee1 , hepatocellular carcinoma , cancer research , cyclin dependent kinase 1 , kinase , apoptosis , biology , cell cycle , cyclin dependent kinase 2 , transforming growth factor , protein kinase a , microbiology and biotechnology , biochemistry

Transforming growth factor-β1 (TGF-β1) potently inhibits human hepatocellular carcinoma (HCC) cell growth. Here we demonstrated that TGF-β1-induced apoptosis is mediated by decreased phosphorylation of cdc2 at Tyr15 accompanied by down-regulation of Wee1 kinase expression. As expected from these results, a Wee1 kinase inhibitor efficiently induced apoptosis in HCC cells in the absence of TGF-β1 treatment. In surgically resected samples, Wee1 kinase was expressed in moderately to poorly differentiated HCC, whereas no Wee1 kinase expression was observed in non-cancerous tissue, including cirrhotic tissue. Our results suggest that Wee1 kinase inhibitors may be a practical novel therapeutic option against advanced HCC.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research