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Background  Tuberculosis (TB) is an infectious disease that remains a major cause of morbidity and mortality worldwide, yet the reasons why only 10% of people infected with  Mycobacterium tuberculosis  go on to develop clinical disease are poorly understood. Genetically determined variation in the host immune response is one factor influencing the response to  M. tuberculosis . SP110 is an interferon-responsive nuclear body protein with critical roles in cell cycling, apoptosis and immunity to infection. However association studies of the gene with clinical TB in different populations have produced conflicting results.    Methods  To examine the importance of the  SP110  gene in immunity to TB in the Vietnamese we conducted a case-control genetic association study of 24  SP110  variants, in 663 patients with microbiologically proven TB and 566 unaffected control subjects from three tertiary hospitals in northern Vietnam.    Results  Five SNPs within  SP110  were associated with all forms of TB, including four SNPs at the C terminus (rs10208770, rs10498244, rs16826860, rs11678451) under a dominant model and one SNP under a recessive model, rs7601176. Two of these SNPs were associated with pulmonary TB (rs10208770 and rs16826860) and one with extra-pulmonary TB (rs10498244).    Conclusion    SP110  variants were associated with increased susceptibility to both pulmonary and extra-pulmonary TB in the Vietnamese. Genetic variants in  SP110  may influence macrophage signaling responses and apoptosis during  M. tuberculosis  infection, however further research is required to establish the mechanism by which  SP110  influences immunity to tuberculosis infection.

Polymorphisms of SP110 Are Associated with both Pulmonary and Extra-Pulmonary Tuberculosis among the Vietnamese