Identification of CD24 as a Cancer Stem Cell Marker in Human Nasopharyngeal Carcinoma | Zendy

ChunHung Yang | Zendy; Huiling Wang | Zendy; YiSheng Lin | Zendy; Krishan Kumar | Zendy; HungChi Lin | Zendy; ChihJung Chang | Zendy; ChiaChen Lu | Zendy; TsungTeng Huang | Zendy; Jan Martel | Zendy; David M. Ojcius | Zendy; YuSun Chang | Zendy; John D. Young | Zendy; HsinChih Lai | Zendy

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Identification of CD24 as a Cancer Stem Cell Marker in Human Nasopharyngeal Carcinoma

Author(s) -

ChunHung Yang,

Huiling Wang,

YiSheng Lin,

Krishan Kumar,

HungChi Lin,

ChihJung Chang,

ChiaChen Lu,

TsungTeng Huang,

Jan Martel,

David M. Ojcius,

YuSun Chang,

John D. Young,

HsinChih Lai

Publication year - 2014

Publication title -

plos one

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.99

H-Index - 332

ISSN - 1932-6203

DOI - 10.1371/journal.pone.0099412

Subject(s) - sox2 , homeobox protein nanog , cancer stem cell , nasopharyngeal carcinoma , cd24 , cd44 , biology , cancer research , stem cell , wnt signaling pathway , population , stem cell marker , cell , immunology , embryonic stem cell , microbiology and biotechnology , medicine , signal transduction , induced pluripotent stem cell , genetics , gene , environmental health , radiation therapy

Cancer stem cells (CSCs) represent a unique sub-population of tumor cells with the ability to initiate tumor growth and sustain self-renewal. Although CSC biomarkers have been described for various tumors, only a few markers have been identified for nasopharyngeal carcinoma (NPC). In this study, we show that CD24 + cells isolated from human NPC cell lines express stem cell genes ( Sox2 , Oct4 , Nanog , Bmi-1 , and Rex-1 ), and show activation of the Wnt/β-catenin signaling pathway. CD24 + cells possess typical CSC characteristics that include enhanced cell proliferation, increased colony and sphere formation, maintenance of cell differentiation potential in prolonged culture, and enhanced resistance to chemotherapeutic drugs. Notably, CD24 + cells produce tumors following inoculation of as few as 500 cells in immunodeficient NOD/SCID mice. CD24 + cells further show increased invasion ability in vitro , which correlates with enhanced expression of matrix metalloproteinase 2 and 9. In summary, our results suggest that CD24 represents a novel CSC biomarker in NPC.

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