Correction: Combined Acquisition Technique (CAT) for Neuroimaging of Multiple Sclerosis at Low Specific Absorption Rates (SAR)

Figure 2. Measurement protocol and Visual Rating Scale (VRS). The order of CAT and TSE sequences was varied by rotation according to a Latin square. Upon measurement of a CAT/TSE double (A) the patient rated the two sequences in comparison to each other. Ratings scored sensations of temperature (RF-induced heating), acoustic noise and scan vibrations (B). Negative VRS values indicate less heating, acoustic noise and scan vibrations during CAT vs. TSE imaging, positive values indicate that higher temperatures, acoustic noise and vibration levels were perceived during CAT vs. TSE imaging while zero refers to no subjective difference between the CAT and TSE. doi:10.1371/journal.pone.0091030.g002 Figure 3. TSE and CAT brain images in Multiple Sclerosis (MS). Exemplary T2(upper row) and PD-weighted images acquired by TSE (left column) and CAT (right column) sequences are shown. The data from this representative patient illustrate, along with those from another in Fig. 5, the diagnostic equivalence of both MR techniques: Every lesion picked up on the TSE image is detected on the CAT image as well. Minimally reduced SNR of CAT compared to TSE which has previously been quantified [7] is noticeable upon close visual inspection but does not impede diagnostic accuracy (spatial noise ratio of TSE to CAT was 0.82 for T2and 0.88 for PD-weighted images). doi:10.1371/journal.pone.0091030.g003