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Background  Obesity is associated with excessive consumption of palatable, energy dense foods. The present study used an animal model to examine feeding patterns during exposure to and withdrawal from these foods.    Methods  Male Sprague Dawley rats were exposed to standard lab chow only (Chow rats) or a range of cafeteria-style foods eaten by people (Caf rats). After 1, 4, 7 and 10 weeks of diet in their home cage, rats were subjected to 24-hour test sessions in a Comprehensive Lab Animal Monitoring System (CLAMS). In the first two test sessions, Chow rats were exposed to standard lab chow only while Caf rats were exposed to a biscuit and high-fat chow diet. In the final two test sessions, half the rats in each group were switched to the opposing diet. In each session we recorded numbers of bouts, energy consumed per bout, and intervals between bouts across the entire 24 hours.    Results  Relative to Chow rats, Caf rats initiated fewer bouts but consumed more energy per bout; however, their motivation to feed in the CLAMS declined over time, which was attributed to reduced variety of foods relative to their home cage diet. This decline in motivation was especially pronounced among Caf rats switched from the palatable CLAMS diet to standard lab chow only: the reduced energy intake in this group was due to a modest decline in bout frequency and a dramatic decline in bout size.    Conclusions  Exposure to a cafeteria-diet, rich in variety, altered feeding patterns, reduced rats' motivation to consume palatable foods in the absence of variety, and further diminished motivation to feed when palatable foods were withdrawn and replaced with chow. Hence, variety is a key factor in driving excessive consumption of energy dense foods, and therefore, excessive weight gain.

Rats Eat a Cafeteria-Style Diet to Excess but Eat Smaller Amounts and Less Frequently when Tested with Chow