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The severe adverse reaction to vitamin K 1  injection is always remarkable and is thought to result from anaphylaxis. Paradoxically, however, some patients administered vitamin K 1  injection for the first time have adverse reactions. Using beagle dogs, the present study tested the hypothesis that the response to vitamin K 1  is an anaphylactoid reaction. The results showed that serious anaphylaxis-like symptoms appeared in beagle dogs after the administration of vitamin K 1  injection for the first time. The plasma histamine concentration increased, and blood pressure decreased sharply. After sensitization, dogs were challenged with vitamin K 1  injection and displayed the same degree of symptoms as prior to sensitization. However, when the vitamin K 1  injection-sensitized dogs were challenged with a vitamin K 1 -fat emulsion without solubilizers such asTween-80, the abnormal reactions did not occur. Furthermore, there was no significant change in the plasma immunoglobulin E concentration after vitamin K 1  challenge. Following treatment with vitamin K 1  injection, the release of histamine and β-hexosaminidase by rat basophilic leukemia-2H3 cells as well as the rate of apoptosis increased. The Tween-80 group displayed results similar to those observed following vitamin K 1  injection in vivo. However, the dogs in the vitamin K 1 -fat emulsion group did not display any abnormal behavior or significant change in plasma histamine. Additionally, degranulation and apoptosis did not occur in rat basophilic leukemia-2H3 cells. Our results indicate that the adverse reaction induced by vitamin K 1  injection is an anaphylactoid reaction, not anaphylaxis. Vitamin K 1  injection induces the release of inflammatory factors via a non-IgE-mediated immune pathway, for which the trigger may be the solubilizer.

The Severe Adverse Reaction to Vitamin K1 Injection Is Anaphylactoid Reaction but Not Anaphylaxis