Knockdown of miR-214 Promotes Apoptosis and Inhibits Cell Proliferation in Nasopharyngeal Carcinoma | Zendy

Zi-Chen Zhang | Zendy; Yang Yang Li | Zendy; Haiyun Wang | Zendy; Sha Fu | Zendy; Xiao-Pai Wang | Zendy; MuSheng Zeng | Zendy; Yi Zeng | Zendy; Jian-Yong Shao | Zendy

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Knockdown of miR-214 Promotes Apoptosis and Inhibits Cell Proliferation in Nasopharyngeal Carcinoma

Author(s) -

Zi-Chen Zhang,

Yang Yang Li,

Haiyun Wang,

Sha Fu,

Xiao-Pai Wang,

MuSheng Zeng,

Yi Zeng,

Jian-Yong Shao

Publication year - 2014

Publication title -

plos one

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.99

H-Index - 332

ISSN - 1932-6203

DOI - 10.1371/journal.pone.0086149

Subject(s) - nasopharyngeal carcinoma , gene knockdown , cancer research , cell growth , microrna , carcinogenesis , apoptosis , gene silencing , cell culture , luciferase , in vivo , biology , cancer , medicine , transfection , radiation therapy , biochemistry , genetics , microbiology and biotechnology , gene

MicroRNA-214 (MiR-214) is aberrantly expressed in several human tumors such as ovarian cancer and breast cancer. However, the role of miR-214 in nasopharyngeal carcinoma (NPC) is still unknown. In this study, we report that miR-214 was overexpressed in NPC cell lines and tissues. Silencing of miR-214 by LNA-antimiR-214 in NPC cells resulted in promoting apoptosis and suppressing cell proliferation in vitro , and suppressed tumor growth in nude mice in vivo . Luciferase reporter assay was performed to identify Bim as a direct target of miR-214. Furthermore, this study showed that low Bim expression in NPC tissues correlated with poor survival of NPC patients. Taken together, our findings suggest that miR-214 plays an important role in NPC carcinogenesis.

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