Characterization of the yehUT Two-Component Regulatory System of Salmonella enterica Serovar Typhi and Typhimurium | Zendy

Vanessa Wong | Zendy; Derek Pickard | Zendy; Lars Barquist | Zendy; Karthikeyan Sivaraman | Zendy; Andrew J. Page | Zendy; P. John Hart | Zendy; Mark J. Arends | Zendy; Kathryn E. Holt | Zendy; Leanne Kane | Zendy; Lynda Mottram | Zendy; Louise Ellison | Zendy; Ruben Bautista | Zendy; Chris McGee | Zendy; Sally Kay | Zendy; Thomas M. Wileman | Zendy; Linda J. Kenney | Zendy; Calman A. MacLennan | Zendy; Robert A. Kingsley | Zendy; Gordon Dougan | Zendy

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Characterization of the yehUT Two-Component Regulatory System of Salmonella enterica Serovar Typhi and Typhimurium

Author(s) -

Vanessa Wong,

Derek Pickard,

Lars Barquist,

Karthikeyan Sivaraman,

Andrew J. Page,

P. John Hart,

Mark J. Arends,

Kathryn E. Holt,

Leanne Kane,

Lynda Mottram,

Louise Ellison,

Ruben Bautista,

Chris McGee,

Sally Kay,

Thomas M. Wileman,

Linda J. Kenney,

Calman A. MacLennan,

Robert A. Kingsley,

Gordon Dougan

Publication year - 2013

Publication title -

plos one

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.99

H-Index - 332

ISSN - 1932-6203

DOI - 10.1371/journal.pone.0084567

Subject(s) - salmonella enterica , biology , salmonella typhi , salmonella , microbiology and biotechnology , serotype , transcriptome , gene , pathogen , mutant , bacteria , genetics , escherichia coli , gene expression

Proteins exhibiting hyper-variable sequences within a bacterial pathogen may be associated with host adaptation. Several lineages of the monophyletic pathogen Salmonella enterica serovar Typhi (S. Typhi) have accumulated non-synonymous mutations in the putative two-component regulatory system yehUT . Consequently we evaluated the function of yehUT in S. Typhi BRD948 and S . Typhimurium ST4/74. Transcriptome analysis identified the cstA gene, encoding a carbon starvation protein as the predominantly yehUT regulated gene in both these serovars. Deletion of yehUT had no detectable effect on the ability of these mutant Salmonella to invade cultured epithelial cells ( S. Typhi and S . Typhimurium) or induce colitis in a murine model ( S . Typhimurium only). Growth, metabolic and antimicrobial susceptibility tests identified no obvious influences of yehUT on these phenotypes.

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