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Proteins exhibiting hyper-variable sequences within a bacterial pathogen may be associated with host adaptation. Several lineages of the monophyletic pathogen  Salmonella enterica  serovar Typhi (S. Typhi) have accumulated non-synonymous mutations in the putative two-component regulatory system  yehUT . Consequently we evaluated the function of  yehUT  in  S.  Typhi BRD948 and  S . Typhimurium ST4/74. Transcriptome analysis identified the  cstA  gene, encoding a carbon starvation protein as the predominantly  yehUT  regulated gene in both these serovars. Deletion of  yehUT  had no detectable effect on the ability of these mutant  Salmonella  to invade cultured epithelial cells ( S.  Typhi and  S . Typhimurium) or induce colitis in a murine model ( S . Typhimurium only). Growth, metabolic and antimicrobial susceptibility tests identified no obvious influences of  yehUT  on these phenotypes.

Characterization of the yehUT Two-Component Regulatory System of Salmonella enterica Serovar Typhi and Typhimurium