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Analysis of rhesus macaques infected with a  vpx  deletion mutant virus of simian immunodeficiency virus mac239 (SIVΔ vpx ) demonstrates that Vpx is essential for efficient monocyte/macrophage infection  in vivo  but is not necessary for development of AIDS. To compare myeloid-lineage cell infection in monkeys infected with SIVΔ vpx  compared to SIVmac239, we analyzed lymphoid and gastrointestinal tissues from SIVΔ vpx -infected rhesus (n = 5), SIVmac239-infected rhesus with SIV encephalitis (7 SIV239E), those without encephalitis (4 SIV239noE), and other SIV mutant viruses with low viral loads (4 SIVΔ nef , 2 SIVΔ3). SIV+ macrophages and the percentage of total SIV+ cells that were macrophages in spleen and lymph nodes were significantly lower in rhesus infected with SIVΔ vpx  (2.2%) compared to those infected with SIV239E (22.7%), SIV239noE (8.2%), and SIV mutant viruses (10.1%). In colon, SIVΔ vpx  monkeys had fewer SIV+ cells, no SIV+ macrophages, and lower percentage of SIV+ cells that were macrophages than the other 3 groups. Only 2 SIVΔ vpx  monkeys exhibited detectable virus in the colon. We demonstrate that Vpx is essential for efficient macrophage infection  in vivo  and that simian AIDS and death can occur in the absence of detectable macrophage infection.

SIV Vpx Is Essential for Macrophage Infection but Not for Development of AIDS