The Small Molecule Wnt Signaling Modulator ICG-001 Improves Contractile Function in Chronically Infarcted Rat Myocardium | Zendy

Tomoyo Sasaki | Zendy; Hyosook Hwang | Zendy; Cu Nguyen | Zendy; Robert A. Kloner | Zendy; Michaël Kahn | Zendy

Open Access

The Small Molecule Wnt Signaling Modulator ICG-001 Improves Contractile Function in Chronically Infarcted Rat Myocardium

Author(s) -

Tomoyo Sasaki,

Hyosook Hwang,

Cu Nguyen,

Robert A. Kloner,

Michaël Kahn

Publication year - 2013

Publication title -

plos one

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.99

H-Index - 332

ISSN - 1932-6203

DOI - 10.1371/journal.pone.0075010

Subject(s) - wnt signaling pathway , myocardial infarction , cardiac function curve , progenitor cell , ejection fraction , regeneration (biology) , cardiology , medicine , microbiology and biotechnology , stem cell , chemistry , signal transduction , biology , heart failure

The adult mammalian heart has limited capability for self-repair after myocardial infarction. Therefore, therapeutic strategies that improve post-infarct cardiac function are critically needed. The small molecule ICG-001 modulates Wnt signaling and increased the expression of genes beneficial for cardiac regeneration in epicardial cells. Lineage tracing experiments, demonstrated the importance of β-catenin/p300 mediated transcription for epicardial progenitor contribution to the myocardium. Female rats given ICG-001 for 10 days post-occlusion significantly improved ejection fraction by 8.4%, compared to controls ( P <0.05). Taken together, Wnt modulation via β-catenin/CBP inhibition offers a promising therapeutic strategy towards restoration of myocardial tissues and an enhancement of cardiac functions following infarction.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research