Mechanistic Comparison between Gastric Bypass vs. Duodenal Switch with Sleeve Gastrectomy in Rat Models | Zendy

Yosuke Kodama | Zendy; Helene Johannessen | Zendy; Marianne W. Furnes | Zendy; ChunMei Zhao | Zendy; Gjermund Johnsen | Zendy; Ronald Mårvik | Zendy; Bård Kulseng | Zendy; Duan Chen | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Mechanistic Comparison between Gastric Bypass vs. Duodenal Switch with Sleeve Gastrectomy in Rat Models

Author(s) -

Yosuke Kodama,

Helene Johannessen,

Marianne W. Furnes,

ChunMei Zhao,

Gjermund Johnsen,

Ronald Mårvik,

Bård Kulseng,

Duan Chen

Publication year - 2013

Publication title -

plos one

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.99

H-Index - 332

ISSN - 1932-6203

DOI - 10.1371/journal.pone.0072896

Subject(s) - sleeve gastrectomy , weight loss , malabsorption , gastrectomy , energy expenditure , laparotomy , medicine , gastric bypass , body weight , calorimeter (particle physics) , duodenal switch , gastroenterology , surgery , zoology , biology , physics , obesity , cancer , detector , optics

Background Both gastric bypass (GB) and duodenal switch with sleeve gastrectomy (DS) have been widely used as bariatric surgeries, and DS appears to be superior to GB. The aim of this study was to better understand the mechanisms leading to body weight loss by comparing these two procedures in experimental models of rats. Methods Animals were subjected to GB, DS or laparotomy (controls), and monitored by an open-circuit indirect calorimeter composed of comprehensive laboratory animal monitoring system and adiabatic bomb calorimeter. Results Body weight loss was greater after DS than GB. Food intake was reduced after DS but not GB. Energy expenditure was increased after either GB or DS. Fecal energy content was increased after DS but not GB. Conclusion GB induced body weight loss by increasing energy expenditure, whereas DS induced greater body weight loss by reducing food intake, increasing energy expenditure and causing malabsorption in rat models.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research