Phenotypic Alteration of Neutrophils in the Blood of HIV Seropositive Patients | Zendy

Tom Cloke | Zendy; Markus Munder | Zendy; Philip Bergin | Zendy; S. Herath | Zendy; Manuel Modolell | Zendy; Graham P. Taylor | Zendy; Ingrid Müller | Zendy; Pascale Kropf | Zendy

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Phenotypic Alteration of Neutrophils in the Blood of HIV Seropositive Patients

Author(s) -

Tom Cloke,

Markus Munder,

Philip Bergin,

S. Herath,

Manuel Modolell,

Graham P. Taylor,

Ingrid Müller,

Pascale Kropf

Publication year - 2013

Publication title -

plos one

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.99

H-Index - 332

ISSN - 1932-6203

DOI - 10.1371/journal.pone.0072034

Subject(s) - phenotype , peripheral blood mononuclear cell , immunology , biology , population , human immunodeficiency virus (hiv) , peripheral blood , blood cell , medicine , gene , in vitro , genetics , environmental health

We have recently identified a novel population of activated low-density granulocytes (LDGs) in peripheral blood mononuclear cells of HIV seropositive patients. LDGs have a similar morphology to normal density granulocytes (NDGs), but are phenotypically different. Here we measured the expression levels of different phenotypic markers of granulocytes in the blood of HIV seropositive patients at different stages of HIV infection to determine whether the phenotype of NDGs and LDGs are affected by disease severity. Our results reveal that the phenotype of NDGs, but not that of LDGs, varies according to the severity of the disease.

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