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Background  The associations between the  interleukin-4 receptor α chain  ( IL4RA ) I50V and Q551R polymorphisms and asthma risk remained controversial.    Methods  We searched the Pubmed, Embase, Chinese National Knowledge Infrastructure (CNKI) and Wanfang databases for studies published before February 2013. The strengths of the associations were calculated using odds ratios (ORs) with 95% confidence intervals (CIs).    Results  A total of 50 studies were included in this meta-analysis. There was a significant association between the  IL4RA  I50V polymorphism and asthma risk in a dominant genetic model (OR = 1.13, 95% CI 1.04–1.23,  P  = 0.005). The  IL4RA  Q551R polymorphism was associated with a significantly elevated asthma risk in a recessive genetic model (OR = 1.46, 95% CI 1.22–1.75,  P <0.0001). Subgroup analyses found that the  IL4RA  I50V polymorphism was significantly associated with asthma risk in Asians (OR = 1.72, 95% CI 1.31–2.25,  P <0.0001), pediatric asthma risk (OR = 1.50, 95% CI 1.13–1.99,  P  = 0.005), and atopic asthma risk (OR = 1.88, 95% CI 1.27–2.79,  P  = 0.002).    Conclusions  The results of this meta-analysis suggested that the  IL4RA  I50V and Q551R polymorphisms may be risk factors for developing asthma.

Association between Interleukin-4 Receptor α Chain (IL4RA) I50V and Q551R Polymorphisms and Asthma Risk: An Update Meta-Analysis