A Single Nucleotide Polymorphism within the Interferon Gamma Receptor 2 Gene Perfectly Coincides with Polledness in Holstein Cattle | Zendy

Sabrina Glatzer | Zendy; Nina Johanna Merten | Zendy; Claudia Dierks | Zendy; Anne Wöhlke | Zendy; U. Philipp | Zendy; O. Distl | Zendy

Open Access

A Single Nucleotide Polymorphism within the Interferon Gamma Receptor 2 Gene Perfectly Coincides with Polledness in Holstein Cattle

Author(s) -

Sabrina Glatzer,

Nina Johanna Merten,

Claudia Dierks,

Anne Wöhlke,

U. Philipp,

O. Distl

Publication year - 2013

Publication title -

plos one

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.99

H-Index - 332

ISSN - 1932-6203

DOI - 10.1371/journal.pone.0067992

Subject(s) - biology , single nucleotide polymorphism , genetics , haplotype , genotyping , snp , candidate gene , locus (genetics) , quantitative trait locus , gene , genotype

Polledness is a high impact trait in modern milk and beef production to meet the demands of animal welfare and work safety. Previous studies have mapped the polled-locus to the proximal region of the bovine chromosome 1 (BTA1) and narrowed it down to approximately 1 Mb. Sequencing of the positional candidate genes within the 1 Mb polled region and whole genome sequencing of Holsteins revealed a single nucleotide polymorphism (SNP) AC000158: g.1390292G>A within intron 3 of the interferon gamma receptor 2 gene ( IFNGR2 ) in perfect co-segregation with polledness in Holsteins. This complete association was validated in 443 animals of the same breed. This SNP allows reliable genotyping of horned, heterozygous and homozygous polled Holsteins, even in animals that could not be resolved using the previously published haplotype for Holstein.

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