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The Snail gene family encodes zinc finger-containing transcriptional repressor proteins. Three members of the Snail gene family have been described in mammals, encoded by the  Snai1 ,  Snai2 , and  Snai3  genes. The function of the  Snai1  and  Snai2  genes have been studied extensively during both vertebrate embryogenesis and tumor progression and metastasis, and play critically important roles during these processes. However, little is known about the function of the  Snai3  gene and protein. We describe here generation and analysis of  Snai3  conditional and null mutant mice. We also generated an EYFP-tagged  Snai3  null allele that accurately reflects endogenous  Snai3  gene expression, with the highest levels of expression detected in thymus and skeletal muscle.  Snai3  null mutant homozygous mice are viable and fertile, and exhibit no obvious phenotypic defects. These results demonstrate that  Snai3  gene function is not essential for embryogenesis in mice.

The Snail Family Gene Snai3 Is Not Essential for Embryogenesis in Mice