Glucanase Induces Filamentation of the Fungal Pathogen Candida albicans | Zendy

Hongbin Xu | Zendy; Clarissa J. Nobile | Zendy; Anna DongariBagtzoglou | Zendy

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Glucanase Induces Filamentation of the Fungal Pathogen Candida albicans

Author(s) -

Hongbin Xu,

Clarissa J. Nobile,

Anna DongariBagtzoglou

Publication year - 2013

Publication title -

plos one

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.99

H-Index - 332

ISSN - 1932-6203

DOI - 10.1371/journal.pone.0063736

Subject(s) - filamentation , candida albicans , microbiology and biotechnology , corpus albicans , quorum sensing , biology , glucanase , fungal protein , pathogen , virulence , genetics , gene , saccharomyces cerevisiae , laser , physics , optics

Candida albicans is the most common human fungal pathogen. Many organisms, including C. albicans , secrete glucanases under different environmental conditions. Here, we report a novel role for beta -1, 3- glucanase in inducing Candida albicans to form filaments at 22°C and enhancing filamentation at 37°C in nutrient-rich medium. Quorum sensing, the efg1 -signaling and cek1 MAP kinase pathways are involved in this process. Our data suggest that the natural antifungal agent beta –glucanase may support morphologic transformation of Candida albicans at a wide range of ambient temperatures.

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