Fusion of ZMYND8 and RELA Genes in Acute Erythroid Leukemia | Zendy

Ioannis Panagopoulos | Zendy; Francesca Micci | Zendy; Jim Thorsen | Zendy; Lisbeth Haugom | Zendy; Jochen Buechner | Zendy; Gitte Kerndrup | Zendy; Anne Tierens | Zendy; Bernward Zeller | Zendy; Sverre Heim | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Fusion of ZMYND8 and RELA Genes in Acute Erythroid Leukemia

Author(s) -

Ioannis Panagopoulos,

Francesca Micci,

Jim Thorsen,

Lisbeth Haugom,

Jochen Buechner,

Gitte Kerndrup,

Anne Tierens,

Bernward Zeller,

Sverre Heim

Publication year - 2013

Publication title -

plos one

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.99

H-Index - 332

ISSN - 1932-6203

DOI - 10.1371/journal.pone.0063663

Subject(s) - zinc finger , chromosomal translocation , bromodomain , fusion protein , fusion gene , biology , phd finger , gene , zinc finger nuclease , microbiology and biotechnology , fusion transcript , fluorescence in situ hybridization , ring finger domain , genetics , chromosome , transcription factor , epigenetics , recombinant dna

Acute erythroid leukemia was diagnosed in a 4-month-old boy. Cytogenetic analysis of bone marrow (BM) cells showed a t(11;20)(p11;q11) translocation. RNA extracted from the BM was sequenced and analyzed for fusion transcripts using the software FusionMap. A ZMYND8-RELA fusion was ranked first. RT-PCR and direct sequencing verified the presence of an in frame ZMYND8-RELA chimeric transcript. Fluorescence in situ hybridization showed that the ZMYND8-RELA was located on the p12 band of der(11); therefore a cytogenetically invisible pericentric inversion in chromosome 11 must have taken place besides the translocation. The putative ZMYND8-RELA fusion protein contains the Zinc-PHD finger domain, a bromodomain, a PWWP domain, a MYND type of zinc finger of ZMYND8, and the entire RELA protein, indicating that it might act leukemogenically by influencing several cellular processes including the NF-kappa-B pathway.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research