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We investigated cell cycle progression in epithelial cervical ME-180 cells during colonization of three different  Lactobacillus  species utilizing live cell microscopy, bromodeoxyuridine incorporation assays, and flow cytometry. The colonization of these ME-180 cells by  L. rhamnosus  and  L. reuteri , originating from human gastric epithelia and saliva, respectively, was shown to reduce cell cycle progression and to cause host cells to accumulate in the G1 phase of the cell cycle. The G1 phase accumulation in  L. rhamnosus -colonized cells was accompanied by the up-regulation and nuclear accumulation of p21. By contrast, the vaginal isolate  L. crispatus  did not affect cell cycle progression. Furthermore, both the supernatants from the lactic acid-producing  L. rhamnosus  colonies and lactic acid added to cell culture media were able to reduce the proliferation of ME-180 cells. In this study, we reveal the diversity of the  Lactobacillus  species to affect host cell cycle progression and demonstrate that  L. rhamnosus  and  L. reuteri  exert anti-proliferative effects on human cervical carcinoma cells.

Lactobacillus Decelerates Cervical Epithelial Cell Cycle Progression