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C/EBPα plays important roles in metabolism as well as in the maintenance of energy homeostasis. Here we describe loss of the circadian oscillation of  C/ebpα  expression in liver of  Clock  mutant mice. Reporter assays indicate Clock and Bmal significantly induced  C/ebpα  gene expression whereas Cry suppressed. Real time reporter assays showed that two mutated E-boxes disrupted  C/ebpα  promoter dependent-oscillation. Chromatin immunoprecipitation suggests Clock can bind to two E-boxes in the  C/ebpα  promoter with a circadian manner  in vivo . Thus,  C/ebpα  gene transcription is under circadian control of a core clock component,  Clock . The data suggests that circadian disturbances may affect metabolic abnormalities through the  C/ebpα  pathway in liver.

The Circadian Binding of CLOCK Protein to the Promoter of C/ebpα Gene in Mouse Cells