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A series of  trans -3-aryl acrylic acids  1 – 27  and their derivatives  28 – 34  were prepared and evaluated for their antiviral activity against  tobacco mosaic virus  (TMV) for the first time. The bioassay results showed that most of these compounds exhibited good antiviral activity against TMV, of which compounds  1 ,  5 ,  6 ,  20 ,  27  and  34  exhibited significantly higher activity against TMV than commercial Ribavirin both  in vitro  and  in vivo . Furthermore, these compounds have more simple structure than commercial Ribavirin, and can be synthesized more efficiently. These new findings demonstrate that  trans -3-aryl acrylic acids and their derivatives represent a new template for antiviral studies and could be considered for novel therapy against plant virus infection.

Discovery and SARs of Trans-3-Aryl Acrylic Acids and Their Analogs as Novel Anti- Tobacco Mosaic Virus (TMV) Agents