English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Runx2, a member of the family of runt-related transcription factors, is rhythmically expressed in bone and may be involved in circadian rhythms in bone homeostasis and osteogenesis. Runx2 is also expressed in the brain, but its function is unknown. We tested the hypothesis that in the brain, Runx2 may interact with clock-controlled genes to regulate circadian rhythms in behavior. First, we demonstrated diurnal and circadian rhythms in the expression of Runx2 in the mouse brain. Expression of Runx2 mRNA and protein mirrored that of the core clock genes,  Period1  and  Period2 , in the suprachiasmatic nucleus (SCN), the paraventricular nucleus and the olfactory bulb. The rhythm of  Runx2  expression was eliminated in the SCN of  Bmal1 −/−   mice. Moreover, by crossbreeding  mPer2 Luc   mice with  Runx2 +/−   mice and recording bioluminescence rhythms, a significant lengthening of the period of rhythms was detected in cultured SCN of  Runx2 −/−   animals compared to either  Runx2 +/−   or  Runx2 +/+   mice. Behavioral analyses of Runx2 mutant mice revealed that  Runx2 +/−   animals displayed a significantly lengthened free-running period of running wheel activity compared to  Runx2 +/+   littermates. Taken together, these findings provide evidence for clock gene-mediated rhythmic expression of  Runx2 , and its functional role in regulating circadian period at the level of the SCN and behavior.

The Transcription Factor Runx2 Is under Circadian Control in the Suprachiasmatic Nucleus and Functions in the Control of Rhythmic Behavior