English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

An understanding of why certain  Acinetobacter  species are more successful in causing nosocomial infections, transmission and epidemic spread in healthcare institutions compared with other species is lacking. We used genomic, phenotypic and virulence studies to identify differences between  Acinetobacter  species. Fourteen strains representing nine species were examined. Genomic analysis of six strains showed that the  A. baumannii  core genome contains many genes important for diverse metabolism and survival in the host. Most of the  A. baumannii  core genes were also present in one or more of the less clinically successful species. In contrast, when the accessory genome of an individual  A. baumannii  strain was compared to a strain of a less successful species ( A. calcoaceticus  RUH2202), many operons with putative virulence function were found to be present only in the  A. baumannii  strain, including the  csu  operon, the acinetobactin chromosomal cluster, and bacterial defence mechanisms. Phenotype microarray analysis showed that compared to  A. calcoaceticus  (RUH2202),  A. baumannii  ATCC 19606 T  was able to utilise nitrogen sources more effectively and was more tolerant to pH, osmotic and antimicrobial stress. Virulence differences were also observed, with  A. baumannii  ATCC 19606 T ,  A. pittii  SH024, and  A. nosocomialis  RUH2624 persisting and forming larger biofilms on human skin than  A. calcoaceticus .  A. baumannii  ATCC 19606 T  and  A. pittii  SH024 were also able to survive in a murine thigh infection model, whereas the other two species were eradicated. The current study provides important insights into the elucidation of differences in clinical relevance among  Acinetobacter  species.

The Success of Acinetobacter Species; Genetic, Metabolic and Virulence Attributes