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Following the discovery of synergistic action between oxacillin and manuka honey against methicillin-resistant  Staphylococcus aureus , this study was undertaken to search for further synergistic combinations of antibiotics and honey that might have potential in treating wounds. Fifteen antibiotics were tested with and without sublethal concentrations of manuka honey against each of MRSA and  Pseudomonas aeruginosa  using disc diffusion, broth dilution, E strip, chequerboard titration and growth curves. Five novel antibiotic and manuka honey combinations were found that improved antibacterial effectiveness  in vitro  and these offer a new avenue of future topical treatments for wound infections caused by these two important pathogens.

Improving Antibiotic Activity against Wound Pathogens with Manuka Honey In Vitro