Differential Gene and MicroRNA Expression between Etoposide Resistant and Etoposide Sensitive MCF7 Breast Cancer Cell Lines | Zendy

Karobi Moitra | Zendy; Kate M. Im | Zendy; Katy Limpert | Zendy; Alexander Borsa | Zendy; Julie Sawitzke | Zendy; Robert W. Robey | Zendy; Naoya Yuhki | Zendy; Ram Savan | Zendy; Da Wei Huang | Zendy; Richard A. Lempicki | Zendy; Susan E. Bates | Zendy; Michael Dean | Zendy

Open Access

Differential Gene and MicroRNA Expression between Etoposide Resistant and Etoposide Sensitive MCF7 Breast Cancer Cell Lines

Author(s) -

Karobi Moitra,

Kate M. Im,

Katy Limpert,

Alexander Borsa,

Julie Sawitzke,

Robert W. Robey,

Naoya Yuhki,

Ram Savan,

Da Wei Huang,

Richard A. Lempicki,

Susan E. Bates,

Michael Dean

Publication year - 2012

Publication title -

plos one

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.99

H-Index - 332

ISSN - 1932-6203

DOI - 10.1371/journal.pone.0045268

Subject(s) - etoposide , microrna , biology , drug resistance , cancer research , gene , gene expression , gene expression profiling , computational biology , atp binding cassette transporter , transporter , genetics , bioinformatics , chemotherapy

In order to develop targeted strategies for combating drug resistance it is essential to understand it’s basic molecular mechanisms. In an exploratory study we have found several possible indicators of etoposide resistance operating in MCF7VP cells, including up-regulation of ABC transporter genes, modulation of miRNA, and alteration in copy numbers of genes.

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