Possible Role of the WDR3 Gene on Genome Stability in Thyroid Cancer Patients | Zendy

Wilser Andrés García-Quispes | Zendy; Susana Pastor | Zendy; Pere Galofré | Zendy; Josefina Biarnés | Zendy; Joan Martí i Castell | Zendy; Antonia Velázquez | Zendy; Ricard Marcos | Zendy

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Possible Role of the WDR3 Gene on Genome Stability in Thyroid Cancer Patients

Author(s) -

Wilser Andrés García-Quispes,

Susana Pastor,

Pere Galofré,

Josefina Biarnés,

Joan Martí i Castell,

Antonia Velázquez,

Ricard Marcos

Publication year - 2012

Publication title -

plos one

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.99

H-Index - 332

ISSN - 1932-6203

DOI - 10.1371/journal.pone.0044288

Subject(s) - genome instability , thyroid cancer , binucleated cells , micronucleus , micronucleus test , single nucleotide polymorphism , genotype , biology , gene , microbiology and biotechnology , genetics , dna damage , genome , peripheral blood , ionizing radiation , irradiation , cancer , medicine , dna , immunology , physics , toxicity , nuclear physics

The role of the WDR3 gene on genomic instability has been evaluated in a group of 115 differentiated thyroid cancer (DTC) patients. Genomic instability has been measured according to the response of peripheral blood lymphocytes to ionizing radiation (0.5 Gy). The response has been measured with the micronucleus (MN) test evaluating the frequency of binucleated cells with MN (BNMN), both before and after the irradiation. No differences between genotypes, for the BNMN frequencies previous the irradiation, were observed. Nevertheless significant decreases in DNA damage after irradiation were observed in individuals carrying the variant alleles for each of the three genotyped SNPs: rs3754127 [−8.85 (−15.01 to −2.70), P<0.01]; rs3765501 [−8.98 (−15.61 to −2.36), P<0.01]; rs4658973 [−8.70 (−14.94 to −2.46), P<0.01]. These values correspond to those obtained assuming a dominant model. This study shows for the first time that WDR3 can modulate genome stability.

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