English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Tools annual

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Presents the access of premium content as premium feature

Premium Content

Global: Zendy Plus annual

Global: Zendy Free Plan

Background  High body iron store has been associated with an increased risk of type 2 diabetes (T2D); it remains unknown whether the genetic variants related to body iron status affect T2D risk. We aimed at comprehensively investigating the associations between the genetic variants related to body iron status and the T2D risk.    Methodology/Principal Findings  Six common SNPs related to body iron status from recent genome-wide association (GWA) studies were determined in the Nurses’ Health Study (NHS; 1,467 diabetic cases and 1,754 controls) and the Health Professionals Follow-up Study (HPFS; 1,124, diabetic cases and 1,298 controls). Plasma levels of ferritin, soluble transferrin receptor (sTfR), and transferrin were measured in NHS. Significant associations were observed for loci in  TPMRSS6  with sTfR ( P =  3.47×10 −6 ),  TF  with transferrin ( P  = 0.0002 to 1.72×10 −10 ); and  HFE  with ferritin ( P =  0.017 to 1.6×10 −8 ), sTfR ( P =  0.007 to 7.9×10 −6 ), and transferrin ( P =  0.006 to 0.0007). The six SNPs together explained 5.7%, 2.7%, and 13.3% of the variation in plasma levels of ferritin, sTfR, and transferrin. After adjustment for the conventional risk factors, the T allele of SNP rs855791 in the  TPMRSS6  gene was significantly associated with a 19% decreased risk of T2D (OR = 0.81; 95% CI = 0.66–0.98;  P =  0.03) in men. Multiple tests attenuated this significant association to null. No associations were observed in women. SNPs at  HFE  and  TF  were not associated with diabetes risk in either sex. Dietary iron intake did not modify the associations of the newly identified loci with diabetes risk.    Conclusions/Significance  The newly identified iron-related SNP rs855791 in  TPMRSS6  was nominally associated with a decreased risk of T2D in men but not in women. The apparent differences by gender warrant further study.

Genetic Determinants for Body Iron Store and Type 2 Diabetes Risk in US Men and Women