Differential Trypanocidal Activity of Novel Macrolide Antibiotics; Correlation to Genetic Lineage | Zendy

Carolina Aquilino | Zendy; Maria Luisa Gonzalez Rubio | Zendy; Elena M. Seco | Zendy; Leticia Escudero | Zendy; Laura Corvo | Zendy; Manuel Soto | Zendy; Manuel Fresno | Zendy; Francisco Malpartida | Zendy; Pedro Bonay | Zendy

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Differential Trypanocidal Activity of Novel Macrolide Antibiotics; Correlation to Genetic Lineage

Author(s) -

Carolina Aquilino,

Maria Luisa Gonzalez Rubio,

Elena M. Seco,

Leticia Escudero,

Laura Corvo,

Manuel Soto,

Manuel Fresno,

Francisco Malpartida,

Pedro Bonay

Publication year - 2012

Publication title -

plos one

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.99

H-Index - 332

ISSN - 1932-6203

DOI - 10.1371/journal.pone.0040901

Subject(s) - lineage (genetic) , biology , trypanosoma cruzi , antibiotics , genetics , computational biology , mechanism (biology) , gene , parasite hosting , philosophy , epistemology , world wide web , computer science

Here we report the systematic study of the anti-trypanocidal activity of some new products derived from S. diastatus on 14 different T. cruzi strains spanning the six genetic lineages of T. cruzi . As the traditional growth inhibition curves giving similar IC 50 showed great differences on antibiotic and lineage tested, we decided to preserve the wealth of information derived from each inhibition curve and used an algorithm related to potency of the drugs, combined in a matrix data set used to generate a cluster tree. The cluster thus generated based just on drug susceptibility data closely resembles the phylogenies of the lineages derived from genetic data and provides a novel approach to correlate genetic data with phenotypes related to pathogenesis of Chagas disease. Furthermore we provide clues on the drugs mechanism of action.

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