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Reduced mechanical stress is a major cause of osteoporosis in the elderly, and the osteocyte network, which comprises a communication system through processes and canaliculi throughout bone, is thought to be a mechanosensor and mechanotransduction system; however, the functions of osteocytes are still controversial and remain to be clarified. Unexpectedly, we found that overexpression of  BCL2  in osteoblasts eventually caused osteocyte apoptosis. Osteoblast and osteoclast differentiation were unaffected by  BCL2  transgene in vitro. However, the cortical bone mass increased due to enhanced osteoblast function and suppressed osteoclastogenesis at 4 months of age, when the frequency of TUNEL-positive lacunae reached 75%. In the unloaded condition, the trabecular bone mass decreased in both wild-type and  BCL2  transgenic mice at 6 weeks of age, while it decreased due to impaired osteoblast function and enhanced osteoclastogenesis in wild-type mice but not in  BCL 2 transgenic mice at 4 months of age.  Rankl  and  Opg  were highly expressed in osteocytes, but  Rankl  expression in osteoblasts but not in osteocytes was increased at unloading in wild-type mice but not in  BCL 2 transgenic mice at 4 months of age. Sost was locally induced at unloading in wild-type mice but not in  BCL 2 transgenic mice, and the dissemination of Sost was severely interrupted in  BCL 2 transgenic mice, showing the severely impaired osteocyte network. These findings indicate that the osteocyte network is required for the upregulation of  Rankl  in osteoblasts and Sost in osteocytes in the unloaded condition. These findings suggest that the osteocyte network negatively regulate bone mass by inhibiting osteoblast function and activating osteoclastogenesis, and these functions are augmented in the unloaded condition at least partly through the upregulation of  Rankl  expression in osteoblasts and that of Sost in osteocytes, although it cannot be excluded that low  BCL2  transgene expression in osteoblasts contributed to the enhanced osteoblast function.

Osteocyte Network; a Negative Regulatory System for Bone Mass Augmented by the Induction of Rankl in Osteoblasts and Sost in Osteocytes at Unloading